Increased body mass index is associated with improved overall survival in extranodal natural killer/T-cell lymphoma, nasal type
Metrics: PDF 800 views | HTML 991 views | ?
Ya-Jun Li1,2, Ping-Yong Yi1,2, Ji-Wei Li1,2, Xian-Ling Liu3, Xi-Yu Liu1,2, Fang Zhou1,2, Zhou OuYang1,2, Zhong-Yi Sun1,2, Li-Jun Huang1,2, Jun-Qiao He1,2, Yuan Yao1,2, Zhou Fan1,2, Tian Tang2,4 and Wen-Qi Jiang5,6
1 Department of Lymphoma and Hematology, Hunan Cancer Hospital, Changsha, Hunan, China
2 The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
3 Cancer Center of the Second Xiangya Hospital, Central South University, Changsha, Hunan, China
4 Radioactive Interventional Department, Hunan Cancer Hospital, Changsha, Hunan, China
5 State Key Laboratory of Oncology in South China, Guangzhou, China
6 Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China
Ping-Yong Yi, email:
Wen-Qi Jiang, email:
Keywords: body mass index, extranodal natural killer/T-cell lymphoma, prognosis, IPI, KPI
Received: April 26, 2016 Accepted: November 30, 2016 Published: December 16, 2016
Objectives: The role of body mass index (BMI) in lymphoma survival outcomes is controversial. The prognostic significance of BMI in extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is unclear. We evaluated the prognostic role of BMI in patients with ENKTL.
Methods: We retrospectively analyzed 742 patients with newly diagnosed ENKTL. The prognostic value of BMI was compared between patients with low BMIs (< 20.0 kg/m2) and patients with high BMIs (≥ 20.0 kg/m2). The prognostic value of the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI) was also evaluated and compared with that of the BMI classification.
Results: Patients with low BMIs tended to exhibit higher Eastern Cooperative Oncology Group performance status (ECOG PS) scores (≥ 2) (P = 0.001), more frequent B symptoms (P < 0.001), lower albumin levels (P < 0.001), higher KPI scores (P = 0.03), and lower rates of complete remission (P < 0.001) than patients with high BMIs, as well as inferior progression-free survival (PFS, P = 0.003), and inferior overall survival (OS, P = 0.001). Multivariate analysis demonstrated that age > 60 years, mass > 5 cm, stage III/IV, elevated LDH levels, albumin levels < 35 g/L and low BMIs were independent adverse predictors of OS. The BMI classification was found to be superior to the IPI with respect to predicting patient outcomes among low-risk patients and the KPI with respect to distinguishing between intermediate-low- and high-intermediate-risk patients.
Conclusions: Higher BMI at the time of diagnosis is associated with improved overall survival in ENKTL. Using the BMI classification may improve the IPI and KPI prognostic models.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.