Association between the HOTAIR polymorphisms and cancer risk: an updated meta-analysis

Zhao-Xiong Zhang; Xue Tong; Wan-Ni Zhang; Wei-Neng Fu

doi:10.18632/oncotarget.13880

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Association between the HOTAIR polymorphisms and cancer risk: an updated meta-analysis

Zhao-Xiong Zhang, Xue Tong, Wan-Ni Zhang and Wei-Neng Fu _

PDF | HTML | How to cite

Oncotarget. 2017; 8:4460-4470. https://doi.org/10.18632/oncotarget.13880

Metrics: PDF 2395 views | HTML 2112 views | ?

Abstract

Zhao-Xiong Zhang1, Xue Tong1, Wan-Ni Zhang1, Wei-Neng Fu1

1Department of Medical Genetics, China Medical University, Shenyang, 110122, P.R. China

Correspondence to:

Wei-Neng Fu, email: [email protected]

Keywords: HOTAIR, SNP, cancer, susceptible risk, meta-analysis

Received: July 15, 2016 Accepted: December 01, 2016 Published: December 10, 2016

ABSTRACT

Purpose: LncRNA HOTAIR plays an important role in many cancer. Several studies have shown that some HOTAIR SNPs might be associated with tumor risk in case-control studies, but the results are inconsistent and inconclusive. Therefore, it is necessary to better evaluate association between the HOTAIR SNPs and the risk of cancer.

Results: rs920778, rs7958904 and rs874945 but not rs4759314 and rs1899663 loci were significantly related to cancer risk, among of which rs920778 and rs874945 increased and rs7958904 decreased cancer risk, respectively. Moreover, rs920778 is significantly susceptible in both Asian population and digestive cancer risks.

Materials and Methods: Data were collected from PubMed, Embase and Web of Science. A total of 11 case-control studies were selected for the quantitative analysis. Software Stata (Version 12) was used to calculate Odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the strength of the associations. Subgroup analysis, sensitivity analysis, and publication bias were also performed. Five HOTAIR SNPs were finally enrolled in the study.

Conclusions: HOTAIR SNP rs920778, rs7958904 and rs874945 are susceptible to cancer risk. SNP rs920778 is also a useful risk factor in evaluation of Asian population and digestive cancer. In addition, the cancer risk SNP rs874945 is first reported in the meta-analysis.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 13880

Publication Alerts

Research Papers:

Association between the HOTAIR polymorphisms and cancer risk: an updated meta-analysis

Abstract