Oncotarget

Research Papers:

The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition

Carmine Onofrillo _, Alice Galbiati, Lorenzo Montanaro and Massimo Derenzini

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Oncotarget. 2017; 8:4257-4267. https://doi.org/10.18632/oncotarget.13833

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Abstract

Carmine Onofrillo1, Alice Galbiati1, Lorenzo Montanaro1, Massimo Derenzini1

1Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, S. Orsola Hospital, 40138, Bologna, Italy

Correspondence to:

Carmine Onofrillo, email: carmine.onofrillo@unibo.it

Keywords: ribosome biogenesis inhibition, 5S rRNA, ribosomal proteins, MDM2, p53

Received: December 16, 2015     Accepted: December 03, 2016     Published: December 09, 2016

ABSTRACT

Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we report that MDM2 inhibition is dependent by a pre-existing population of 5S rRNA.


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