Oncotarget

Research Papers:

Long non-coding RNA XIST promotes cell growth and invasion through regulating miR-497/MACC1 axis in gastric cancer

Lei Ma _, Yongjian Zhou, Xiaojun Luo, Hai Gao, Xubin Deng and Yingjie Jiang

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Oncotarget. 2017; 8:4125-4135. https://doi.org/10.18632/oncotarget.13670

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Abstract

Lei Ma1,6,*, Yongjian Zhou2,*, Xiaojun Luo3, Hai Gao4,5, Xubin Deng1, Yingjie Jiang2,*

1Cancer Hospital of Guangzhou Medical University, Guangzhou, China

2Department of Gastroenterology, the First Hospital of Guangzhou, Guangzhou, China

3Cancer Center, TCM-Integrated Hospital, Southern Medical University, Guangzhou, China

4Xiamen Hospital of Traditional Chinese Medicine, Xiamen, China

5Xiamen Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Xiamen, China

6Department of Gastroenterology, Guangzhou Medical University, Guangzhou, China

*These authors contributed equally to this work

Correspondence to:

Lei ma, email: leima_01@yeah.net

Xiaojun Luo, email: carl@smu.edu.cn

Hai Gao, email: hai_gao@126.com

Xubin Deng, email: xubindeng@126.com

Keywords: lncRNA XIST, miR-497, MACC1, gastric cancer

Received: April 20, 2016     Accepted: October 19, 2016     Published: November 28, 2016

ABSTRACT

Abnormal expression of long non-coding RNA (lncRNAs) often contributes to unrestricted growth and invasion of cancer cells. LncRNA XIST expression is up-regulated in several cancers, however, its modulatory mechanism in gastric cancer (GC) has not been elucidated. In the present study, we found that XIST expression was significantly increased in GC tissues and cell lines. LncRNA XIST promoted cell cycle progression from the G1 phase to the S phase and protected cells from apoptosis, which contributed to GC cell growth. LncRNA XIST also contributed to GC cell invasion both in vitro and in vivo. We revealed that XIST functioned as competing endogenous RNA to repress miR-497, which controlled its down-stream target MACC1. We proposed that XIST was responsible for GC cell proliferation and invasion and XIST exerted its function through the miR-497/MACC1 axis. Our findings suggested that lncRNA XIST may be a candidate prognostic biomarker and a target for new therapies in GC patients.


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