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The association between the TP53 Arg72Pro polymorphism and colorectal cancer: An updated meta-analysis based on 32 studies

Xin Tian _, Shundong Dai, Jing Sun, Shenyi Jiang and Youhong Jiang

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Oncotarget. 2017; 8:1156-1165. https://doi.org/10.18632/oncotarget.13589

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Abstract

Xin Tian1, Shundong Dai2,3, Jing Sun4, Shenyi Jiang5, Youhong Jiang1

1Molecular Oncology Laboratory of Cancer Research Institute, The First Affiliated Hospital of China Medical University, Shenyang, 110001, PR China

2Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, 110001, PR China

3Institute of Pathology and Pathophysiology, Shenyang, 110001, PR China

4Department of Immunology and Biotherapy, Liaoning Cancer Hospital and Institute, Shenyang, 110042, PR China

5Department of Rheumatology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, PR China

Correspondence to:

Xin Tian, email: [email protected]

Keywords: TP53, colorectal cancer, polymorphism, meta-analysis

Received: July 05, 2016    Accepted: November 08, 2016    Published: November 25, 2016

ABSTRACT

Several previous studies evaluated the association between the Arg72Pro (rs1042522) polymorphism in the TP53 tumor suppressor gene and colorectal cancer (CRC). However, the results are conflicting. This meta-analysis aimed to shed new light on the precise association between TP53 variants and CRC. We analyzed 32 published case-control studies involving 8,586 cases and 10,275 controls using crude odd ratios (ORs) with 95% confidence intervals (CIs). The meta-analysis was performed using a fixed-effect or random-effects model, as appropriate. We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population. However, subgroup analysis based on ethnicity revealed an increased risk of CRC among Asians (CC vs. GC+GG: OR=1.22, 95% CI: 1.02-1.45), and similar results were found for rectal cancer (CC vs. GC+GG: OR=1.34, 95% CI: 1.120-1.62). These results suggest that the TP53 Arg72Pro polymorphism CC genotype may contribute to an increased risk of CRC, especially for rectal cancer and among Asians.


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