Differentiated regulation of immune-response related genes between LUAD and LUSC subtypes of lung cancers

Mengzhu Chen; Xiuying Liu; Jie Du; Xiu-Jie Wang; Lixin Xia

doi:10.18632/oncotarget.13346

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Research Papers:

Differentiated regulation of immune-response related genes between LUAD and LUSC subtypes of lung cancers

Mengzhu Chen, Xiuying Liu, Jie Du, Xiu-Jie Wang _ and Lixin Xia

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Oncotarget. 2017; 8:133-144. https://doi.org/10.18632/oncotarget.13346

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Abstract

Mengzhu Chen1, Xiuying Liu2, Jie Du3, Xiu-Jie Wang2, Lixin Xia1

1State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Department of Biochemistry and Molecular Biology, Health Science Center of Shenzhen University, School of Medicine, Shenzhen University, Guangdong 518060, China

2Key Laboratory of Genetic Network Biology, Collaborative Innovation Center of Genetics and Development, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

3Beijing Anzhen Hospital, Capital Medical University, Beijing Collaborative Innovative Center for Cardiovascular Disorders, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China

Correspondence to:

Xiu-Jie Wang, email: [email protected]

Lixin Xia, email: [email protected]

Keywords: LUAD, LUSC, immune-response related genes, expression features, cancer progression rate

Received: August 23, 2016 Accepted: October 29, 2016 Published: November 15, 2016

ABSTRACT

Lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) are the two major subtypes of lung cancer, with LUSC exhibits faster progression rate than LUAD. To investigate the roles of immune-response related genes (IRGs) in lung cancer progression, we used LUAD and LUSC samples at different cancer progression stages, and identified that the expression profiles of IRGs could serve as a better classification marker for cancerous tissues of both LUAD and LUSC. We found that the expression changes of IRGs were different between LUAD and LUSC. Cell cycle promoting genes, including KIFs and proteasomes, showed faster up-regulation in LUSC, whereas immune response promoting genes, including MHC molecules and chemokines, were more rapidly repressed in LUSC. Comparative pathway analysis revealed that members of the Toll-like receptor and T cell receptor signaling pathways exhibited diverged expression changes between LUAD and LUSC, especially at the early cancer stages. Our results revealed the difference of LUAD and LUSC from the immune response point of view, and provided new clues for the differential treatment of LUAD and LUSC.

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Research Papers:

Differentiated regulation of immune-response related genes between LUAD and LUSC subtypes of lung cancers

Abstract