Research Papers:
Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma
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Abstract
Ting-Ying Fu1,2,*, Chao-Nan Wu3,4,*, Huei-Cin Sie1, Jiin-Tsuey Cheng5, Yaoh-Shiang Lin6, Huei-Han Liou7, Yu-Kai Tseng8,9, Chih-Wen Shu7, Kuo-Wang Tsai7,10, Leing-Ming Yen1, Hui-Wen Tseng11,12, Ching-Jiunn Tseng7,13,14,15, Luo-Ping Ger7,16, Pei-Feng Liu7,17
1Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
2Department of Optometry, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan
3Department of Stomatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
4Department of Dental Technology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan
5Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan
6Department of Otorhinolaryngology-Head & Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
7Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
8Department of Orthopedics, Show Chwan Memorial Hospital, Changhua, Taiwan
9Department of Orthopedics, National Cheng Kung University Hospital, Tainan, Taiwan
10Department of Chemical Biology, National Pingtung University of Education, Pingtung, Taiwan
11Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
12Department of Nursing, Meiho University, Pingtung, Taiwan
13Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
14Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan
15Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan
16Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan
17Department of Biotechnology, Fooyin University, Kaohsiung, Taiwan
*These authors have contributed equally to this work
Correspondence to:
Luo-Ping Ger, email: [email protected]
Pei-Feng Liu, email: [email protected]
Keywords: DDX60, oral cancer, subsite-specific, tumorigenesis, prognosis
Received: April 14, 2016 Accepted: October 28, 2016 Published: November 08, 2016
ABSTRACT
The clinical significance and biological function of DEXD/H box helicase 60 (DDX60) in oral cancer remains unknown. Herein, we evaluated the association of DDX60 expression with tumorigenesis and the prognosis of oral squamous cell carcinoma (OSCC). DDX60 expression was examined by immunohistochemistry on tissue microarray slides of 494 OSCC patients, including 180 buccal mucosal SCC (BMSCC), 241 tongue SCC (TSCC), and 73 lip SCC (LSCC) patients. DDX60 expression was significantly increased in all three subsites of OSCC compared to its expression in tumor adjacent normal tissues. However, its association with tumorigenesis was specific to the oral cavity subsite after the stratification of betel quid chewing, smoking, and drinking. Among OSCC patients, higher levels of DDX60 expression were associated with the male gender, a well-differentiated tumor, advanced stage of disease, and a large tumor size with subsite specific features. LSCC patients with high DDX60 expression levels showed shorter disease-specific survival, particularly those with moderately or poorly differentiated tumors. Additionally, TSCC or OSCC patients with high DDX60 expression showed a poor disease-free survival (DFS), particularly those with moderately or poorly differentiated tumors. Therefore, DDX60 is a novel and unfavorable biomarker for tumorigenesis and prognosis of OSCC in a subsite-specific manner.
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