Oncotarget

Research Papers:

Multiple mutations of lung squamous cell carcinoma shared common mechanisms

Qianping Li, Junyi Hou, Zhaoyan Hu, Biao Gu and Yan Shi _

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Oncotarget. 2016; 7:79629-79636. https://doi.org/10.18632/oncotarget.13190

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Abstract

Qianping Li1,*, Junyi Hou2,*, Zhaoyan Hu3, Biao Gu4, Yan Shi5

1Department of Cardiothoracic Surgery, Shanghai University of Medicine & Health Sciences Shanghai Sixth People‘s Hospital East Campus, Shanghai, PR China

2Department of Gastroenterology, Shanghai University of Medicine & Health Sciences Shanghai Sixth People‘s Hospital East Campus, Shanghai, PR China

3Hangzhou Cancer Institute, Hangzhou cancer hospital, Hangzhou City, PR China

4Department of Thoracic Surgery, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an, Jiangsu, China

5Department of Emergency, The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’an, Huai’an, China

*Co-first authors

Correspondence to:

Biao Gu, email: prof_zh@sina.com

Yan Shi, email: jfmsy@163.com

Keywords: lung squamous cell carcinoma, mutation, the cancer genome atlas, mRNA

Received: July 04, 2016     Accepted: October 19, 2016     Published: November 07, 2016

ABSTRACT

Lung squamous cell carcinoma (LUSC) is a subtype of non-small cell lung cancers which is the cause of 80% of all lung cancer deaths. The genes that highly mutated in patients with LUSC and their roles played in the tumorigenesis remains unknown. Data of patients with Lung squamous cell carcinoma (LUSC) were retrieved from The Cancer Genome Atlas (TCGA). Differentially expressed genes were identified between control and cancer samples. Patients and controls can be separated by mRNA expression level showing that the between-group variance and totally 1265 genes were differentially expressed between controls and patients. Top genes whose mutations highly occurred in patients with LUSC were identified, most of these genes were shown to be related with tumorigenesis in previous studies. All of the genes mostly mutated were independently correlated with expression levels of all genes. These mutations did not show the trend of co-occurrence. However, the influenced gene of these mutations had overlaps. After studying the intersection of these genes, a group of shared genes were identified. The shared pathways enriched which played critical role in LUSC were identified based on these shared genes. Different mutations had contribution to the progression of LUSC. Though these genes involved different specific mechanisms, most of them may share a common mechanism which is critical for LUSC. The results may suggest a neglected mechanism and also indicate a potential target for therapies.


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