Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer

Shanshan Wu; Xiangfei Zhao; Sudong Wu; Rui Du; Qi Zhu; Henghu Fang; Xinhong Zhang; Chunyang Zhang; Wei Zheng; Jihua Yang; Huasong Feng

doi:10.18632/oncotarget.13177

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer

Shanshan Wu, Xiangfei Zhao, Sudong Wu, Rui Du, Qi Zhu, Henghu Fang, Xinhong Zhang, Chunyang Zhang, Wei Zheng, Jihua Yang and Huasong Feng _

PDF | HTML | How to cite

Oncotarget. 2016; 7:81750-81756. https://doi.org/10.18632/oncotarget.13177

Metrics: PDF 1998 views | HTML 2700 views | ?

Abstract

Shanshan Wu1,2,*, Xiangfei Zhao2,*, Sudong Wu2, Rui Du2, Qi Zhu2, Henghu Fang2, Xinhong Zhang2, Chunyang Zhang2, Wei Zheng2, Jihua Yang2, Huasong Feng2

1Postgraduate Team, Chinese PLA General Hospital, Beijing 100853, China

2Department of Radiation Oncology, Navy General Hospital, Beijing 100048, China

*These authors have contributed equally to this work

Correspondence to:

Huasong Feng, email: [email protected]

Keywords: meta-analysis, B7-H3, prognosis, lung cancer, clinical

Received: September 08, 2016 Accepted: October 19, 2016 Published: November 07, 2016

ABSTRACT

Previous studies have investigated the prognostic significance of B7 homolog 3 (B7-H3) in non-small cell lung cancer (NSCLC), however, the results remain controversial. This study was aimed to determine the correlation between B7-H3 and survival as well as clnicalpathological characteristics in NSCLC using meta-analysis. We searched the electronic databases of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) for relevant studies up to October 9, 2016. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were used to estimate the impact of B7-H3 on overall survival (OS). Combined odds ratios (ORs) and 95%CIs were utilized to evaluate the correlations between B7-H3 and clinicalpathological features. This meta-analysis finally included 7 studies with 864 patients. The results showed that B7-H3 had no significant association with OS (HR=0.88, 95%CI: 0.36-2.13, p=0.776). High B7-H3 expression was a significant indicator of lymph node metastasis (OR=3.92, 95%CI: 2.65-5.81, p<0.001), and advanced TNM stage (OR=3.53, 95%CI: 2.45-5.09, p<0.001). B7-H3 has the potential to serve as a marker of tumor aggressiveness and lymph node metastasis in NSCLC. However, due to several limitations, further large-scale studies are needed to validate our results.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 13177

Publication Alerts

Research Papers:

Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer

Abstract