Tumor necrosis factor-alpha promoter polymorphism 308 G/A is not significantly associated with esophageal cancer risk: a meta-analysis
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Ming Luo1,*, Yuan Yang2,*, Dongmei Luo3,*, Liang Liu4,*, Yuening Zhang5, Feifan Xiao5, Jingcheng Yang2, Chengdong Zhang1,2,6,7, Shen Fu6,7, Zhiguo Luo1
1Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China
2School of Life Sciences, Fudan University, Shanghai, China
3School of Mathematics and Physics, Anhui University of technology, Maanshan, Anhui, China
4Department of Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China
5Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China
6Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China
7Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
*These authors have contributed equally to this work and share first authorship
Shen Fu, email: email@example.com
Zhiguo Luo, email: firstname.lastname@example.org
Keywords: esophageal cancer, TNF-α-308 G/A, meta-analysis, risk, association
Received: June 06, 2016 Accepted: October 21, 2016 Published: November 4, 2016
Many studies have investigated the association between Tumor necrosis factor-α-308 G>A (rs1800629) and the risk of esophageal cancer. However, their results are inconsistent. Therefore, we performed a meta-analysis of available data to investigate any possible association between this polymorphism and esophageal cancer risk. We searched PubMed, EMBASE, Web of Science, and the CNKI database for articles published up to 2016. Crude and adjusted odds ratio with 95% confidence intervals were calculated using fixed or random effects models. We used a dominant model (GA+AA vs GG), a recessive model (AA vs GG+GA), an over-dominant model (GG+AA vs GA), and allele frequency (G vs A) to identify any association. Eleven studies with 5617 participants were included in the meta-analysis. Our results suggest that TNF-α-308 G>A (rs1800629) is not significantly associated with a risk of esophageal squamous cell carcinoma and esophageal adenocarcinoma. For genetic association studies, negative results of meta-analysis have a high level of evidence, and these results are important in this era of high-throughput sequencing-based precision medicine.
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