Oncotarget

Research Papers:

Disadvantage of survival outcomes in widowed patients with colorectal neuroendocrine neoplasm: an analysis of surveillance, epidemiology and end results database

Jing Li _, Ying Wang, Fang Han, Zhu Wang, Lichun Xu and Jiandong Tong

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Oncotarget. 2016; 7:83200-83207. https://doi.org/10.18632/oncotarget.13078

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Abstract

Jing Li1,2, Ying Wang1, Fang Han1, Zhu Wang1,*, Lichun Xu2,*, Jiandong Tong1,*

1Department of Oncology, Yangzhou NO.1 People’s Hospital, The Second Clinical School of Yangzhou University, Yangzhou, Jiangsu Province, China

2Research Center of Cancer Prevention and Treatment, Medical College of Yangzhou University, Yangzhou, Jiangsu Province, China

*Co-corresponding authors

Correspondence to:

Jiandong Tong, email: drtong_yz@163.com

Lichun Xu, email: xzyxyxlc@sohu.com

Zhu Wang, email: wangzhu@msn.cn

Keywords: colorectal neuroendocrine neoplasms, marital status, prognostic analysis

Received: May 03, 2016    Accepted: October 19, 2016    Published: November 4, 2016

ABSTRACT

Marital status correlates with health. Our goal was to examine the impact of marital status on the survival outcomes of patients with colorectal neuroendocrine neoplasms (NENs). The Surveillance, Epidemiology and End Results program was used to identify 1,289 eligible patients diagnosed between 2004 and 2010 with colorectal NENs. Statistical analyses were performed using Chi-square, Kaplan–Meier, and Cox regression proportional hazards methods. Patients in the widowed group had the highest proportion of larger tumor (>2cm), and higher ratio of poor grade (Grade III and IV) and more tumors at advanced stage (P<0.05). The 5-year cause specific survival (CSS) was 76% in the married group, 51% in the widowed group, 73% in the single group, and 72% in the divorced/separated group, which manifest statistically significant difference in the univariate log-rank test and Cox regression model (P<0.05). Furthermore, marital status was an independent prognostic factor only in Distant stage (P<0.001). In conclusion, patients in widowed group were at greater risk of cancer specific mortality from colorectal NENs and social support may lead to improved outcomes for patients with NENs.


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