Serum monocyte fraction of white blood cells is increased in patients with high Gleason score prostate cancer

Takuji Hayashi; Kazutoshi Fujita; Go Tanigawa; Atsunari Kawashima; Akira Nagahara; Takeshi Ujike; Motohide Uemura; Tetsuya Takao; Seiji Yamaguchi; Norio Nonomura

doi:10.18632/oncotarget.13052

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Clinical Research Papers:

Serum monocyte fraction of white blood cells is increased in patients with high Gleason score prostate cancer

Takuji Hayashi _, Kazutoshi Fujita, Go Tanigawa, Atsunari Kawashima, Akira Nagahara, Takeshi Ujike, Motohide Uemura, Tetsuya Takao, Seiji Yamaguchi and Norio Nonomura

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:35255-35261. https://doi.org/10.18632/oncotarget.13052

Metrics: PDF 1721 views | HTML 3703 views | ?

Abstract

Takuji Hayashi1, Kazutoshi Fujita1, Go Tanigawa2, Atsunari Kawashima1, Akira Nagahara1, Takeshi Ujike1, Motohide Uemura1, Tetsuya Takao2, Seiji Yamaguchi2 and Norio Nonomura1

1 Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan

2 Department of Urology, Osaka General Medical Center, Osaka, Japan

Correspondence to:

Kazutoshi Fujita, email:

Keywords: serum, monocyte, Gleason score, prostate cancer, biopsy

Received: September 16, 2016 Accepted: October 28, 2016 Published: November 03, 2016

Abstract

Systemic inflammation and immune responses are reported to be associated with progressive prostate cancer. In this study, we explored which among the fractions of white blood cell (WBC) and C-reactive protein (CRP) level were associated with high Gleason score prostate cancer. Prostate needle biopsy was performed in 966 men with suspicion of prostate cancer. We assessed age, serum prostate-specific antigen (PSA), prostate volume, WBC count, fractions of WBCs (neutrophils, lymphocytes, monocytes, basophils, and eosinophils), and CRP level before biopsy for associations with biopsy findings. Among all men, 553 (57.2%) were positive for prostate cancer including 421 with high Gleason score cancer (Gleason score ≥7). Age, PSA, PSA density (PSAD), serum monocyte fraction of WBC, monocyte-to-lymphocyte ratio (MLR), and CRP were significantly associated with high Gleason score cancer (p<0.01). Multivariate analysis showed that age, PSA, PSAD, and serum monocyte fraction were significantly associated with high Gleason score prostate cancer (p <0.01). In 571 patients with PSA of <10 ng/ml, age, PSA, PSAD, serum WBC count, neutrophil fraction, monocyte fraction, and MLR were significantly associated with high Gleason score prostate cancer (p<0.05). Multivariate analysis showed that age, PSAD, and serum monocyte fraction were significantly associated with high Gleason score prostate cancer (p<0.01). The monocyte fraction of WBCs was increased in patients with high Gleason score prostate cancer, suggesting an interaction of monocytes with the progression of prostate cancer.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 13052

Publication Alerts

Clinical Research Papers:

Serum monocyte fraction of white blood cells is increased in patients with high Gleason score prostate cancer

Abstract