Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma
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Qianqian Wang2,*, Xiangyuan Yu2,*, Qiang Li2, Linyuan Qin2, Shengkui Tan2, Xiaoyun Zeng1, Xiaoqiang Qiu1, Bo Tang3, Junfei Jin3, Weijia Liao3, Moqin Qiu3, Lijun Tan3, Gaofeng He3, Xiaomei Li2, Songqing He3,4, Hongping Yu1,2
1Department of Epidemiology and Health Statistics, Guangxi Medical University, Nanning 530021, China
2Department of Epidemiology, School of Public Health, Guilin Medical University, Guilin 541004, China
3Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China
4Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Guilin Medical University, Guilin 541001, China
*These authors contributed equally to this work
Hongping Yu, email: email@example.com
Songqing He, email: firstname.lastname@example.org
Keywords: hepatocellular carcinoma, miR-199a, MET, single nucleotide polymorphism, risk
Received: April 22, 2016 Accepted: October 21, 2016 Published: November 02, 2016
MicroRNAs (miRNAs) can regulate gene expression at post-transcriptional levels, thereby influence cancer risk. The aim of the current study is to investigate association between miR-199a rs74723057 and MET rs1621 and HCC risk in 1032 HCC patients and 1060 cancer-free controls. These two SNPs were genotyped by using the Agena MassARRAY genotyping system. Odds ratio (OR) and 95% confidence interval (95%CI) were calculated to assess the strength of the associations. We found that compared with the wild-type AA genotype of MET rs1621, the variant GG genotype was associated with a decreased risk for HCC (OR = 0.24, 95% CI = 0.06–0.96, P = 0.043). No association between miR-199a rs74723057 and HCC risk was observed. In addition, an interaction effect on HCC risk between the selected two SNPs was found. Among those who carried the CG/GG genotypes of miR-199a rs74723057, those who carried the GG genotype of MET rs1621 had a reduced risk of HCC, when compared with those who carried the AG/AA genotypes of MET rs1621 (OR = 0.15, 95% CI = 0.03~0.73, P for interaction = 0.018). Our results suggest that MET rs1621 polymorphism, alone and combined with miR-199a rs74723057, may influence susceptibility to HCC. Further large-scale association studies and functional studies are needed to validate our findings.
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