Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma
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Jingjing Yu1, Yuling Huang2, Lijuan Liu3, Jing Wang2, Jiye Yin4, Lihua Huang5, Shaojun Chen6, Jingao Li2, Hong Yuan1, Guoping Yang1, Wenyu Liu7, Hai Wang8, Qi Pei1, Chengxian Guo1
1Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China
2Department of Radiation Oncology, Jiangxi Province Tumor Hospital, Nanchang, Jiangxi 330029, China
3Department of Pharmacy, Jiangxi Cancer Hospital, Nanchang 330029, China
4Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
5Center for Medical Experiments, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China
6Department of Oncology, Fourth Affiliated Hospital, Guangxi Medical University, Liuzhou, Guangxi 545005, China
7College of Pharmacy, Central South University, Changsha, Hunan 410008, China
8Xiangya Medical College, Central South University, Changsha, Hunan 410008, China
Chengxian Guo, email: email@example.com
Keywords: nasopharyngeal carcinoma (NPC), Wnt/β-catenin pathway, single nucleotide polymorphism (SNP), curative efficacy, toxic reaction
Received: May 22, 2016 Accepted: October 14, 2016 Published: October 19, 2016
Radiotherapy (RT) is the normative therapeutic treatment for primary nasopharyngeal carcinoma (NPC). Single nucleotide polymorphisms (SNPs) of genes in Wnt/β-catenin pathway are correlated to the development, prognosis, and treatment benefit of various cancers. However, it has not been established whether SNPs of Wnt/β-catenin pathway are associated with nasopharyngeal tumorigenesis and the efficacy of RT in NPC patients. Therefore, in this study, we aimed to investigate the nine potentially functional SNPs of four genes in the Wnt/β-catenin pathway and genotyped these in 188 NPC patients treated with RT. To achieve this goal, associations between these SNPs and the RT’s curative efficacy, as well as acute radiation-induced toxic reaction were determined by multifactorial logistic regression. We observed that catenin beta 1 gene (CTNNB1) rs1880481 and rs3864004, and glycogen synthase kinase 3 beta gene (GSK3β) rs3755557 polymorphisms were significantly associated with poorer efficacy of RT in NPC patients. Moreover, GSK3β rs375557 and adenomatous polyposis coli gene (APC) rs454886 polymorphisms were correlated with acute grade 3–4 radiation-induced dermatitis and oral mucositis, respectively. In conclusion, this study suggests that gene polymorphisms of Wnt/β-catenin may be novel prognostic factors for NPC patients treated with RT.
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