Spc24 is required for meiotic kinetochore-microtubule attachment and production of euploid eggs

Teng Zhang; Yang Zhou; Hong-Hui Wang; Tie-Gang Meng; Lei Guo; Xue-Shan Ma; Wei Shen; Heide Schatten; Qing-Yuan Sun

doi:10.18632/oncotarget.12453

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Research Papers:

Spc24 is required for meiotic kinetochore-microtubule attachment and production of euploid eggs

Teng Zhang, Yang Zhou, Hong-Hui Wang, Tie-Gang Meng, Lei Guo, Xue-Shan Ma, Wei Shen, Heide Schatten and Qing-Yuan Sun _

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Oncotarget. 2016; 7:71987-71997. https://doi.org/10.18632/oncotarget.12453

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Abstract

Teng Zhang1,2,*, Yang Zhou2,4,*, Hong-Hui Wang2, Tie-Gang Meng2,4, Lei Guo2, Xue-Shan Ma2, Wei Shen1, Heide Schatten3, Qing-Yuan Sun1,2,4

1Institute of Reproductive Sciences, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China

2State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

3Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA

4University of the Chinese Academy of Sciences, Beijing, China

*These authors contributed equally to this work

Correspondence to:

Qing-Yuan Sun, email: [email protected]

Keywords: Spc24, meiosis, oocyte, kinetochore-microtubule attachment, aneuploidy

Received: July 10, 2016 Accepted: September 29, 2016 Published: October 04, 2016

ABSTRACT

Mammalian oocytes are particularly error prone in chromosome segregation during two successive meiotic divisions. The proper kinetochore-microtubule attachment is a prerequisite for faithful chromosome segregation during meiosis. Here, we report that Spc24 localizes at the kinetochores during mouse oocyte meiosis. Depletion of Spc24 using specific siRNA injection caused defective kinetochore-microtubule attachments and chromosome misalignment, and accelerated the first meiosis by abrogating the kinetochore recruitment of spindle assembly checkpoint protein Mad2, leading to a high incidence of aneuploidy. Thus, Spc24 plays an important role in genomic stability maintenance during oocyte meiotic maturation.

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Research Papers:

Spc24 is required for meiotic kinetochore-microtubule attachment and production of euploid eggs

Abstract