Oncotarget

Clinical Research Papers:

Correlation analysis between 2D and quasi-3D gamma evaluations for both intensity-modulated radiation therapy and volumetric modulated arc therapy

Jung-in Kim, Chang Heon Choi, Hong-Gyun Wu, Jin Ho Kim, Kyubo Kim and Jong Min Park _

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Oncotarget. 2017; 8:5449-5459. https://doi.org/10.18632/oncotarget.12279

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Abstract

Jung-in Kim1,2,3, Chang Heon Choi1,2,3,4, Hong-Gyun Wu1,2,3,5, Jin Ho Kim1,2,3, Kyubo Kim6 and Jong Min Park1,2,3,4

1 Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea

2 Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea

3 Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

4 Center for Convergence Research on Robotics, Advanced Institutes of Convergence Technology, Suwon, Republic of Korea

5 Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea

6 Department of Radiation Oncology, Ewha Womans University School of Medicine, Seoul, Republic of Korea

Correspondence to:

Jong Min Park, email:

Keywords: 2D gamma evaluation, quasi-3D gamma evaluation, pre-treatment patient-specific quality assurance, intensity-modulated radiation therapy, volumetric modulated arc therapy

Received: July 04, 2016 Accepted: September 21, 2016 Published: September 27, 2016

Abstract

The aim of this work was to investigate correlations between 2D and quasi-3D gamma passing rates. A total of 20 patients (10 prostate cases and 10 head and neck cases, H&N) were retrospectively selected. For each patient, both intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) plans were generated. For each plan, 2D gamma evaluation with radiochromic films and quasi-3D gamma evaluation with fluence measurements were performed with both 2%/2 mm and 3%/3 mm criteria. Gamma passing rates were grouped together according to delivery techniques and treatment sites. Statistical analyses were performed to examine the correlation between 2D and quasi-3D gamma evaluations. Statistically significant difference was observed between delivery techniques only in the quasi-3D gamma passing rates with 2%/2 mm. Statistically significant differences were observed between treatment sites in the 2D gamma passing rates (differences of less than 8%). No statistically significant correlations were observed between 2D and quasi-3D gamma passing rates except the VMAT group and the group including both IMRT and VMAT with 3%/3 mm (r = 0.564 with p = 0.012 for theVMAT group and r = 0.372 with p = 0.020 for the group including both IMRT and VMAT), however, those were not strong. No strong correlations were observed between 2D and quasi-3D gamma evaluations.


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