Supraclavicular and/or celiac lymph node metastases from thoracic esophageal squamous cell carcinoma did not compromise survival following neoadjuvant chemoradiotherapy and surgery

Won Kyung Cho; Dongryul Oh; Yong Chan Ahn; Young Mog Shim; Jae Ill Zo; Jong-Mu Sun; Myung-Ju Ahn; Keunchil Park

doi:10.18632/oncotarget.12200

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Clinical Research Papers:

Supraclavicular and/or celiac lymph node metastases from thoracic esophageal squamous cell carcinoma did not compromise survival following neoadjuvant chemoradiotherapy and surgery

Won Kyung Cho, Dongryul Oh, Yong Chan Ahn _, Young Mog Shim, Jae Ill Zo, Jong-Mu Sun, Myung-Ju Ahn and Keunchil Park

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Oncotarget. 2017; 8:3542-3552. https://doi.org/10.18632/oncotarget.12200

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Abstract

Won Kyung Cho1,*, Dongryul Oh1,*, Yong Chan Ahn1, Young Mog Shim2, Jae Ill Zo2, Jong-Mu Sun3, Myung-Ju Ahn3 and Keunchil Park3

1 Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Korea

2 Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Korea

3 Medicine (Division of Hematology-Oncology), Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Korea

* These authors have equally contributed to this manuscript as the first authors

Correspondence to:

Yong Chan Ahn, email: ,

Keywords: esophageal cancer, neoadjuvant chemoradiotherapy, supraclavicular lymph node, celiac lymph node, staging

Received: May 11, 2016 Accepted: September 16, 2016 Published: September 22, 2016

Abstract

This study is to evaluate the prognostic significance of supraclavicular and/or celiac lymph node (LN) metastases in locally advanced thoracic esophageal squamous cell carcinoma (ESCC) patients treated with neoadjuvant chemoradiotherapy (NACRT) and surgery. Among the total 199 patients, 75 (37.7%) had supraclavicular and/or celiac LN metastasis. Surgery was performed following NACRT in 168 patients (84.4%). After the median 18.7 (1.0-147.2) months’ follow-up, 2-year rates of progression-free survival (PFS) and overall survival (OS) in all patients were 48.1% and 65.7%, respectively. In multivariate analyses, negative surgical margin (p < 0.001), ypT0 stage (p = 0.004), and ypN0 stage (p = 0.020) were significantly favorable factors for PFS, and negative surgical margin (p < 0.001) was the only significantly favorable factor for OS. Metastasis to the supraclavicular and/or celiac LNs was significant factor neither for PFS (p = 0.311) nor OS (p = 0.515). Supraclavicular and/or celiac LN metastasis did not compromise the clinical outcomes following NACRT and surgery.

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Clinical Research Papers:

Supraclavicular and/or celiac lymph node metastases from thoracic esophageal squamous cell carcinoma did not compromise survival following neoadjuvant chemoradiotherapy and surgery

Abstract