Oncotarget

Clinical Research Papers:

The role of cerebral blood flow gradient in peritumoral edema for differentiation of glioblastomas from solitary metastatic lesions

Lin Lin, Yunjing Xue, _ Qing Duan, Bin Sun, Hailong Lin, Xinming Huang, Xiaodan Chen

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Oncotarget. 2016; 7:69051-69059. https://doi.org/10.18632/oncotarget.12053

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Abstract

Lin Lin1, Yunjing Xue1, Qing Duan1, Bin Sun1, Hailong Lin1, Xinming Huang1 and Xiaodan Chen2

1 Department of Radiology, Union Hospital of Fujian Medical University, Fuzhou, Fujian, China

2 Department of Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China

Correspondence to:

Yunjing Xue, email:

Keywords: three-dimensional arterial spin labeling, cerebral blood flow, perfusion, glioblastoma, metastasis

Received: May 04, 2016 Accepted: September 02, 2016 Published: September 15, 2016

Abstract

Objective: Differentiation of glioblastomas from solitary brain metastases using conventional MRI remains an important unsolved problem. In this study, we introduced the conception of the cerebral blood flow (CBF) gradient in peritumoral edema—the difference in CBF values from the proximity of the enhancing tumor to the normal-appearing white matter, and investigated the contribution of perfusion metrics on the discrimination of glioblastoma from a metastatic lesion.

Materials and Methods: Fifty-two consecutive patients with glioblastoma or a solitary metastatic lesion underwent three-dimensional arterial spin labeling (3D-ASL) before surgical resection. The CBF values were measured in the peritumoral edema (near: G1; Intermediate: G2; Far: G3). The CBF gradient was calculated as the subtractions CBFG1 –CBFG3, CBFG1 – CBFG2 and CBFG2 – CBFG3. A receiver operating characteristic (ROC) curve analysis was used to seek for the best cutoff value permitting discrimination between these two tumors.

Results: The absolute/related CBF values and the CBF gradient in the peritumoral regions of glioblastomas were significantly higher than those in metastases(P < 0.038). ROC curve analysis reveals, a cutoff value of 1.92 ml/100g for the CBF gradient of CBFG1 –CBFG3 generated the best combination of sensitivity (92.86%) and specificity (100.00%) for distinguishing between a glioblastoma and metastasis.

Conclusion: The CBF gradient in peritumoral edema appears to be a more promising ASL perfusion metrics in differentiating high grade glioma from a solitary metastasis.


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