Oncotarget

Research Papers:

Analysis of the variability among radiation oncologists in delineation of the postsurgical tumor bed based on 4D-CT

Wei Wang, Jianbin Li _, Jun Xing, Min Xu, Qian Shao, Tingyong Fan, Bing Guo and Shanshan Liu

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Oncotarget. 2016; 7:70516-70523. https://doi.org/10.18632/oncotarget.12044

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Abstract

Wei Wang1, Jianbin Li1, Jun Xing1, Min Xu1, Qian Shao1, Tingyong Fan1, Bing Guo1, Shanshan Liu1

1Department of Radiation Oncology, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong province, China, 250117

Correspondence to:

Jianbin Li, email: lijianbin@msn.com

Keywords: breast-conserving treatment, tumor bed delineation, surgical clip number, CT slice thickness, cavity visualization score

Received: March 09, 2016     Accepted: August 24, 2016     Published: September 15, 2016

ABSTRACT

Objective: This study investigated interobserver and intraobserver variability in radiation oncologists’ definition of the tumor bed (TB) after breast-conserving surgery (BCS).

Results: The TB volume, CVS and number of surgical clips were not significantly related to intraobserver variability. Moreover, no correlation was noted between CT slice thickness and interobserver variability (Δinter, DSCinter) in TB delineation, and no significant difference was noted among the three groups. The TB volume was negatively correlated with Δinter. DSCinter improved significantly with increased TB volume and decreased Δinter. DSCinter also increased significantly in patients with a CVS of 3 to 5 compared with patients with a CVS of 1 to 2. DSCinter was thus positively correlated with the CVS, with a correlation coefficient of 0.451. The use of 7 to 9 surgical clips neither decreased Δinter nor increased DSCinter.

Materials and Methods: Five or more surgical clips were placed at the TB during lumpectomy. The TB was delineated on the end expiration scan. The data were stratified based on the cavity visualization score (CVS), CT slice thickness and surgical clip number. The Dice similarity coefficient (DSC) and inter(intra)observer variability (Δinter and Δintra) in different groups were evaluated and compared.

Conclusions: Inter(intra)observer variability in TB delineation was decreased for breast cancer patients implanted with 5 or more surgical clips in the cohort with a higher CVS and a larger TB. The use of more than 6 surgical clips did not significantly improve TB delineation, so 5 to 6 surgical clips are likely adequate to delineate the TB.


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