Oncotarget

Research Papers:

Comparison of outcomes of tyrosine kinase inhibitor in first- or second-line therapy for advanced non-small-cell lung cancer patients with sensitive EGFR mutations

Jianlin Xu, Xueyan Zhang, Haitang Yang, Guozheng Ding, Bo Jin, Yuqing Lou, Yanwei Zhang, Huimin Wang, Baohui Han _

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Oncotarget. 2016; 7:68442-68448. https://doi.org/10.18632/oncotarget.12035

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Abstract

Jianlin Xu1,*, Xueyan Zhang1,*, Haitang Yang2, Guozheng Ding3, Bo Jin1, Yuqing Lou1, Yanwei Zhang1, Huimin Wang1, Baohui Han1

1Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China

2Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China

3Department of Pulmonary, Anqing Municipal Hospital, Anhui, China

*These authors contributed equally to this work

Correspondence to:

Baohui Han, email: xkyyhan@gmail.com

Keywords: EGFR TKI, NSCLC, first-line, second-line

Received: June 17, 2016     Accepted: September 05, 2016     Published: September 15, 2016

ABSTRACT

Direct comparisons between the use of first- and second-line EGFR tyrosine kinase inhibitor (TKI) in patients with sensitive EGFR mutations are limited. A total of 264 advanced non-small-cell lung cancer (NSCLC) patients with sensitive mutations received EGFR TKI therapy as the first-line therapy, and a total of 187 patients received TKI as the second-line therapy at Shanghai Chest Hospital. First-line EGFR TKI therapy [12.9 months, 95% confidence interval (CI), 10.7–15.2] provided longer progression-free survival (PFS) than did second-line EGFR TKI therapy (9.0 months, 95% CI, 7.7–10.2) [hazard ratio (HR): 0.78, P = 0.034]. The objective response rate (ORR) of first-, and second-line TKI therapy were 67.8% (159/233) and 55.6% (94/169), respectively (P = 0.001). The overall survival (OS) for patients (n = 141) receiving first-line TKI followed by second-line chemotherapy were longer than those for patients (n = 187) receiving first-line chemotherapy followed by second-line TKI (HR: 0.69, P = 0.02).

Compared with second-line TKI, first-line therapy achieved a significant and longer PFS, and higher ORR in the sensitive EGFR mutated NSCLC patients. The therapeutic strategy of using TKI followed by chemotherapy achieved longer OS than that using chemotherapy followed by TKI.


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