A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head
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Jieli Du1,2,*, Wanlin Liu2,*, Tianbo Jin3, Zhenqun Zhao2, Rui Bai2, Huiqin Xue2, Junyu Chen1,2, Mingqi Sun2, Xiyang Zhang3, Guoqiang Wang2, Jianzhong Wang2
1Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050, China
2Department of orthopedics and Traumatology, The 2nd Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China
3The College of Life Sciences, Northwest University, 710069, China
*Co-first authors, these authors contributed equally to this work
Guoqiang Wang, email: firstname.lastname@example.org
Jianzhong Wang, email: email@example.com
Keywords: MMP9, MMP2, single nucleotide polymorphisms, osteonecrosis of the femoral head, association study
Received: May 31, 2016 Accepted: September 05, 2016 Published: September 15, 2016
Osteonecrosis of the femoral head (ONFH) is a common hip joint disease, and steroid-induced ONFH accounts for a large number of cases. Here, we examined eight previously-identified single-nucleotide polymorphisms (SNPs) in the MPP2 and MPP9 genes of 285 steroid-induced ONFH patients and 507 healthy controls from northern China to determine whether these SNPs were associated with the risk of developing steroid-induced ONFH. Chi-squared tests and genetic model and haplotype analyses were used to evaluate associations. The rs2274755 SNP in MMP9 was associated with a decreased risk of steroid-induced ONFH in the allele, dominant, and additive models. Additionally, the “CGC” MMP9 haplotype was associated with a 0.69-fold decrease in the risk of steroid-induced ONFH. Although additional, larger population-based studies are needed to confirm these findings, our results reveal for the first time an association between a MMP9 SNP at the rs2274755 locus and a decreased risk of steroid-induced ONFH in a northern Chinese population.
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