Activation of NLRP1 and NLRP3 inflammasomes contributed to cyclic stretch-induced pyroptosis and release of IL-1β in human periodontal ligament cells

Dan Zhao; Yaqin Wu; Jiabao Zhuang; Chun Xu; Fuqiang Zhang

doi:10.18632/oncotarget.11944

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Research Papers:

Activation of NLRP1 and NLRP3 inflammasomes contributed to cyclic stretch-induced pyroptosis and release of IL-1β in human periodontal ligament cells

Dan Zhao, Yaqin Wu, Jiabao Zhuang, Chun Xu and Fuqiang Zhang _

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Oncotarget. 2016; 7:68292-68302. https://doi.org/10.18632/oncotarget.11944

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Abstract

Dan Zhao1,2,*, Yaqin Wu1,2,*, Jiabao Zhuang1,2, Chun Xu1,2, Fuqiang Zhang1,2

1Department of Prosthodontics, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China

*These authors contributed equally to this work

Correspondence to:

Chun Xu, email: [email protected]

Fuqiang Zhang, email: [email protected]

Keywords: inflammasome, pyroptosis, IL-1β, cyclic stretch, human periodontal ligament cell

Received: July 11, 2016 Accepted: September 07, 2016 Published: September 10, 2016

ABSTRACT

Inflammasomes have been reported to be present in periodontal inflammatory tissue, but the exact role of inflammasomes in periodontal inflammatory reactions especially those related to mechanical stimulations has not been clarified. In this study, it was shown that cyclic stretch activated the nucleotide-binding oligomerization domain-like receptor containing pyrin domain 1 and 3 (NLRP1 and NLRP3) inflammasomes and induced the release of IL-1β and pyroptosis via a caspase-1-related mechanism in human periodontal ligament cells (HPDLCs). This study firstly demonstrated that activation of NLRP inflammasomes contributed to the stretch-induced inflammatory response in HPDLCs. As inflammasomes have been reported to be involved in both programmed cell death and inflammation, further studies are required to elucidate the exact roles and signaling pathway of inflammasomes in stretch-induced periodontal inflammation.

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Research Papers:

Activation of NLRP1 and NLRP3 inflammasomes contributed to cyclic stretch-induced pyroptosis and release of IL-1β in human periodontal ligament cells

Abstract