The association analysis of hOGG1 genetic variants and gastric cancer risk in a Chinese population
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Jiafei Lu1,2,*, Yongmei Yin3,*, Mulong Du1,2,*, Gaoxiang Ma1,2, Yuqiu Ge1,2, Qiang Zhang1,2, Haiyan Chu1,2, Na Tong1,2, Meilin Wang1,2, Jinrong Qiu3,4, Zhengdong Zhang1,2
1Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China
2Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
3Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Biological-Therapy, Eastern Hepatobiliary Surgery Hospital Affiliated to Second Military Medical University, Shanghai, China
*These authors have contributed equally to this work
Zhengdong Zhang, email: email@example.com
Jinrong Qiu, email: firstname.lastname@example.org
Keywords: polymorphism, hOGG1, gastric cancer, susceptibility
Received: March 22, 2016 Accepted: August 24, 2016 Published: September 01, 2016
Human 8-oxoguanine DNA glycosylase (hOGG1) is known to play an important role in the prevention of carcinogenesis, including gastric cancer (GC). We performed a case-control study to investigate whether single nucleotide polymorphisms (SNPs) of hOGG1 are associated with GC risk in a Chinese population. Two potential functional tagSNPs (rs159153 and rs1052133) and a previously reported risk SNP (rs125701) were genotyped in 1,275 GC patients and 1,436 controls. We found that SNP rs125701 G > A was significantly associated with the increased GC risk [adjusted odds ratio (OR) = 1.38, 95% confidence interval (CI) = 1.05-1.79 in additive model]. Besides, the functional studies demonstrated that the minor A allele of rs125701 significantly reduced the transcriptional activity of hOGG1 promoter and enhanced the methylation level of CpG site of cg15357639. In conclusion, our results suggested that the SNP rs125701 in hOGG1 promoter was associated with the elevated GC risk, which could act as a new potential biomarker for GC susceptibility. Further functional verification of rs125701 in GC pathogenesis is warranted.
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