Oncotarget

Research Papers: Gerotarget (Focus on Aging):

Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly

Lisa Rodrigues _, Isabel M. Miranda, Geanne M. Andrade, Marta Mota, Luísa Cortes, Acácio G. Rodrigues, Rodrigo A. Cunha and Teresa Gonçalves

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Oncotarget. 2016; 7:62862-62872. https://doi.org/10.18632/oncotarget.11760

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Abstract

Lisa Rodrigues1,2, Isabel M. Miranda3, Geanne M. Andrade4, Marta Mota1,2, Luísa Cortes1, Acácio G. Rodrigues3, Rodrigo A. Cunha1,2 and Teresa Gonçalves1,2

1 CNC-Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal

2 FMUC-Faculty of Medicine, University of Coimbra, Coimbra, Portugal

3 Department of Microbiology, Cardiovascular Research & Development Unit, CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal

4 Department of Physiology and Pharmacology, Federal University of Ceará, Ceará, Brazil

Correspondence to:

Teresa Gonçalves, email:

Keywords: ageing, infection, gut, Candida albicans, adenosine A2A receptors, Gerotarget

Received: April 05, 2016 Accepted: August 26, 2016 Published: August 31, 2016

Abstract

Opportunistic gut infections and chronic inflammation, in particular due to overgrowth of Candida albicans present in the gut microbiota, are increasingly reported in the elder population. In aged, adult and young mice, we now compared the relative intestinal over-colonization by ingested C. albicans and their translocation to other organs, focusing on the role of adenosine A2A receptors that are a main stop signal of inflammation. We report that elderly mice are more prone to over-colonization by C. albicans than adult and young mice. This fungal over-growth seems to be related with higher growth rate in intestinal lumen, independent of gut tissues invasion, but resulting in higher GI tract inflammation. We observed a particularly high colonization of the stomach, with increased rate of yeast-to-hypha transition in aged mice. We found a correlation between A2A receptor density and tissue damage due to yeast infection: comparing with young and adults, aged mice have a lower gut A2A receptor density and C. albicans infection failed to increase it. In conclusion, this study shows that aged mice have a lower ability to cope with inflammation due to C. albicans over-colonization, associated with an inability to adaptively adjust adenosine A2A receptors density.


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