Oncotarget

Research Papers:

Genetic variants of SOX9 contribute to susceptibility of gliomas among Chinese population

Liang Wang, Gang Li, Nan Liu, Zhen Wang, Xiaoshan Xu, Jing Qi, Dongni Ren, Pengxing Zhang, Yongsheng Zhang and Yanyang Tu _

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Oncotarget. 2016; 7:65916-65922. https://doi.org/10.18632/oncotarget.11679

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Abstract

Liang Wang1,*, Gang Li1,*, Nan Liu2,*, Zhen Wang2, Xiaoshan Xu2, Jing Qi2, Dongni Ren2, Pengxing Zhang2, Yongsheng Zhang3, Yanyang Tu2

1Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China

2Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China

3Department of Administrative, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China

*These authors have contributed equally to this work

Correspondence to:

Yanyang Tu, email: tu.fmmu@gmail.com

Yongsheng Zhang, email: zhangys_td@163.com

Keywords: SOX9, gliomas, polymorphism, genetic susceptibility

Received: June 17, 2016    Accepted: August 15, 2016    Published: August 29, 2016

ABSTRACT

Gliomas make up about 80% of all malignant brain tumors, and cause serious public health problem. Genetic factors and environmental factors jointly caused the development of gliomas, and understanding of the genetic basis is a key component of preventive oncology. However, most genetic factors underlying carcinogenesis of gliomas remain largely unclear. In current study, we systematically evaluated whether genetic variants of SOX9 gene, a transcription factor that plays a central role in the development and differentiation of tumors, contribute to susceptibility of gliomas among Chinese population using a two-stage, case–control study. Results showed that SOX9 rs1042667 was significant associated with increased gliomas risk after adjusted by age, gender, family history of cancer, smoking status and alcohol status (Allele C vs A: OR=1.25; 95% CI=1.11-1.40; P=1.2×10−4). Compared with the carriers of genotype AA, both those of genotype AC (OR=1.37; 95% CI=1.13-1.66) and CC (OR=1.53; 95% CI=1.22-1.91) had significantly increased gliomas risk. This should be the first genetic association study which aims to evaluated the association between genetic variants of SOX9 and susceptibility of gliomas. Additional functional and association studies with different ethnic groups included are needed to further confirm our results.


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