Oncotarget

Research Papers:

The prognostic value of D-dimer levels in metastatic osteosarcoma patients treated with second-line chemotherapy

Yujing Huang, Bangjian Liu, Yuanjue Sun, Jianjun Zhang, Yang Yao and Aina He _

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Oncotarget. 2016; 7:65568-65576. https://doi.org/10.18632/oncotarget.11571

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Abstract

Yujing Huang1,*, Bangjian Liu2,*, Yuanjue Sun1, Jianjun Zhang1, Yang Yao1, Aina He1

1Department of Oncology, Affiliated Sixth People’s Hospital, Shanghai Jiaotong University, 200233 Shanghai, People’s Republic of China

2Department of Neurology, Affiliated Sixth People’s Hospital, Shanghai Jiaotong University, 200233 Shanghai, People’s Republic of China

*These authors have contributed equally to this work

Correspondence to:

Aina He, email: ai_na_he@yahoo.com

Yang Yao, email: yangyao12@yahoo.com

Keywords: D-dimer, osteosarcoma, chemotherapy response, prognosis, second-line chemotherapy

Received: March 15, 2016    Accepted: August 09, 2016    Published: August 24, 2016

ABSTRACT

We performed a retrospective analysis of 32 metastatic osteosarcoma cases to examine the prognostic value of the plasma D-dimer level. We assessed the D-dimer level before second-line chemotherapy (D1) and the D-dimer level after two cycles of second-line chemotherapy (D2). The change in D-dimer level (ΔD) was defined as D2 minus D1. The overall survival (OS) of patients with a high D1 was significantly shorter than those with a low D1 (median OS, 4.7 vs. 16.2 months, P=0.001). Similar results were observed for the D2 (median OS, 4.7 vs. 8.6 months, P=0.033). Multivariable analysis demonstrated that a high D1 (hazard ratio, 3.375; 95% confidence interval, 1.133–10.053; P=0.029) was an unfavorable independent prognostic factor. The mean D2 of 11 patients with stable disease decreased by 0.69 mg/mL compared to the D1 (P = 0.016). The mean D2 increased by 1.47 mg/mL compared to the D1 in 21 patients with progressive disease (P = 0.004). The data suggest that D-dimer may serve as a prognostic biomarker for metastatic osteosarcoma patients treated with second-line chemotherapy.


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