KLRG1 restricts memory T cell antitumor immunity

Lei Li; Shanshan Wan; Kaixiong Tao; Guobin Wang; Ende Zhao

doi:10.18632/oncotarget.11430

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Research Papers:

KLRG1 restricts memory T cell antitumor immunity

Lei Li, Shanshan Wan, Kaixiong Tao, Guobin Wang _ and Ende Zhao

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Oncotarget. 2016; 7:61670-61678. https://doi.org/10.18632/oncotarget.11430

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Abstract

Lei Li1, Shanshan Wan2, Kaixiong Tao1, Guobin Wang1, Ende Zhao1

1Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

2Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA

Correspondence to:

Guobin Wang, email: [email protected]

Ende Zhao, email: [email protected]

Keywords: KLRG1, senescence, memory T cells, antitumor immunity

Received: April 14, 2016 Accepted: August 13, 2016 Published: August 20, 2016

ABSTRACT

Killer cell lectin-like receptor subfamily G member 1 (KLRG1) has been found on human memory T lymphocytes. However, the roles of KLRG1 on human T cells especially in tumor microenvironment have not been fully understood. Our results showed KLRG1 expression on T cells significantly increased in tumor microenvironment. KLRG1⁺ T cells exhibited poor proliferative capacity with decreased effector cytokine production. Meanwhile, KLRG1⁺ T cells expressed abundant pro-inflammatory cytokines and demonstrated high level of Foxp3 expression. KLRG1⁺ T cells showed decreased expression of miRNA-101 and higher expression of CtBP2. Our results indicated KLRG1 might contribute to the impaired antitumor immunity of memory T cells in tumor microenvironment. Thus, repressing KLRG1 on human memory T cells might be a novel therapeutics against cancer.

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Research Papers:

KLRG1 restricts memory T cell antitumor immunity

Abstract