The etiologic spectrum of head and neck squamous cell carcinoma in young patients

Xin Liu; Xiao-lei Gao; Xin-hua Liang; Ya-ling Tang

doi:10.18632/oncotarget.11265

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The etiologic spectrum of head and neck squamous cell carcinoma in young patients

Xin Liu, Xiao-lei Gao, Xin-hua Liang _ and Ya-ling Tang

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Oncotarget. 2016; 7:66226-66238. https://doi.org/10.18632/oncotarget.11265

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Abstract

Xin Liu1,2, Xiao-lei Gao1,2, Xin-hua Liang1,2 and Ya-ling Tang1,3

1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People’s Republic of China

2 Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People’s Republic of China

3 Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People’s Republic of China

Correspondence to:

Xin-hua Liang, email:

Ya-ling Tang, email:

Keywords: head and neck squamous cell carcinoma, young patient, chronic inflammation, HPV, immunity

Received: October 26, 2015 Accepted: August 08, 2016 Published: August 12, 2016

Abstract

Head and neck squamous cell carcinoma (HNSCC), accounting for more than 80% in head and neck malignancies, kills thousands of people a year in the world. Despite most of the patients are more than 45, and the occurrences of head and neck cancer shows a decreasing trend; however, horribly, the incidences of the patients under 45 years old is steadily increasing. Hence, it’s of vital importance to get more pathogen information about risk factors of HNSCC in children and young adults. This review outlines the etiologic spectrum of HNSCC, especially oral/oropharyngeal squamous cell carcinoma, in patients under 45 years of age.

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The etiologic spectrum of head and neck squamous cell carcinoma in young patients

Abstract