Oncotarget

Research Papers:

The elevated preoperative fasting blood glucose predicts a poor prognosis in patients with esophageal squamous cell carcinoma: The Fujian prospective investigation of cancer (FIESTA) study

Dan Hu, Feng Peng, Xiandong Lin, Gang Chen, Binying Liang, Chao Li, Hejun Zhang, Xuehong Liao, Jinxiu Lin, Xiongwei Zheng and Wenquan Niu _

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Oncotarget. 2016; 7:65247-65256. https://doi.org/10.18632/oncotarget.11247

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Abstract

Dan Hu1,*, Feng Peng2,*, Xiandong Lin1,*, Gang Chen1, Binying Liang3, Chao Li1, Hejun Zhang1, Xuehong Liao1, Jinxiu Lin2, Xiongwei Zheng1, Wenquan Niu4

1Department of Pathology, Fujian Provincial Cancer Hospital, The Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China

2Department of Cardiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China

3Medical-Record Department, Fujian Provincial Cancer Hospital, The Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China

4State Key Laboratory of Medical Genomics, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

*Shared first authors

Correspondence to:

Feng Peng, email: pengfeng@medmail.com.cn

Xiongwei Zheng, email: agu1960@126.com

Wenquan Niu, email: niuwenquan_shcn@163.com

Keywords: fasting blood glucose, esophageal squamous cell carcinoma, prognosis, mortality, FIESTA study

Received: May 09, 2016     Accepted: July 28, 2016     Published: August 12, 2016

ABSTRACT

Diabetes as a latent risk factor for cancer has been extensively investigated, while its postoperative prognosis for esophageal cancer is rarely reported. We therefore sought to assess whether the elevated fasting blood glucose before surgery was associated with poor survival in esophageal cancer patients by eliciting a subset of data from the ongoing Fujian prospective investigation of cancer (FIESTA) study. Over 15-year follow-up, 2535 patients receiving three-field lymphadenectomy were assessable. Only patients with esophageal squamous cell carcinoma (ESCC) (n=2396) were analyzed due to the lower prevalence of the other histological types. In ESCC patients, the follow-up duration ranged from 0.5 to 180 months (median 38.2 months). The median survival time (MST) was remarkably shorter in males than in females (80.7 vs. 180+ months, Log-rank test: P<0.001). In males, the survival was worse in patients with diabetes than those without (MST: 27.9 vs. 111.1 months, Log-rank test: P<0.001). In females, the survivor was improved in patients with diabetes (MST: 71.5 months), but was still worse than patients without diabetes (MST: 180+ months, Log-rank test: P<0.001). The overall multivariate hazard ratio for per unit increment in fasting blood glucose was 1.11 (95% confidence interval or CI: 1.09-1.14, P<0.001) and 1.08 (95% CI: 1.03-1.13, P=0.002) in males and females, respectively. Further survival tree analysis consolidated the discrimination ability of fasting blood glucose for the survival of ESCC patients. Taken together, our findings convincingly demonstrated that the elevated preoperative fasting blood glucose can predict poor survival of ESCC patients, especially in males.


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