Oncotarget

Research Papers: Immunology:

Early evidence of anti-PD-1 activity in enzalutamide-resistant prostate cancer

Julie N. Graff _, Joshi J. Alumkal, Charles G. Drake, George V. Thomas, William L. Redmond, Mohammad Farhad, Jeremy P. Cetnar, Frederick S. Ey, Raymond C. Bergan, Rachel Slottke, Tomasz M. Beer

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Oncotarget. 2016; 7:52810-52817. https://doi.org/10.18632/oncotarget.10547

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Abstract

Julie N. Graff1,2, Joshi J. Alumkal1, Charles G. Drake3, George V. Thomas4, William L. Redmond5, Mohammad Farhad5,6, Jeremy P. Cetnar1, Frederick S. Ey1, Raymond C. Bergan1, Rachel Slottke1 and Tomasz M. Beer1

1 Division of Hematology/Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA

2 VA Portland Health Care System, Portland, OR, USA

3 Sidney Kimmel Comprehensive Cancer Center and the Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

4 Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, OR, USA

5 Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, USA

6 Cell, Developmental, and Cancer Biology Department, Oregon Health and Science University, Portland, OR, USA

Correspondence to:

Julie N. Graff, email:

Keywords: prostate cancer, PD-1, immunotherapy, enzalutamide, Immunology and Microbiology Section, Immune response, Immunity

Received: May 31, 2016 Accepted: June 17, 2016 Published: July 12, 2016

Abstract

While programmed cell death 1 (PD-1) inhibitors have shown clear anti-tumor efficacy in several solid tumors, prior results in men with metastatic castration resistant prostate cancer (mCRPC) showed no evidence of activity. Here we report unexpected antitumor activity seen in mCRPC patients treated with the anti-PD-1 antibody pembrolizumab. Patients with evidence of progression on enzalutamide were treated with pembrolizumab 200 mg IV every 3 weeks for 4 doses; pembrolizumab was added to standard dose enzalutamide. Three of the first ten patients enrolled in this ongoing phase II trial experienced rapid prostate specific antigen (PSA) reductions to ≤ 0.2 ng/ml. Two of these three patients had measurable disease upon study entry; both achieved a partial response. There were three patients with significant immune-related adverse events. One had grade 2 myositis, one had grade 3 hypothyroidism, and one had grade 2 hypothyroidism. None of these patients had a response. Two of the three responders had a baseline tumor biopsy. Immunohistochemistry from those biopsies showed the presence of CD3+, CD8+, and CD163+ leukocyte infiltrates and PD-L1 expression. Genetic analysis of the two responders revealed markers of microsatellite instability in one. The surprising and robust responses seen in this study should lead to re-examination of PD-1 inhibition in prostate cancer.


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