Oncotarget

Research Papers: Gerotarget (Focus on Aging):

Platelets as an indicator of vascular repair in elderly Japanese men

Yuji Shimizu _, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota and Takahiro Maeda

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Oncotarget. 2016; 7:44919-44926. https://doi.org/10.18632/oncotarget.10229

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Abstract

Yuji Shimizu1,2, Shimpei Sato1, Jun Koyamatsu1, Hirotomo Yamanashi3, Mako Nagayoshi1, Koichiro Kadota1 and Takahiro Maeda1,3

1 Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan

2 Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan

3 Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan

Correspondence to:

Yuji Shimizu, email:

Keywords: platelets, vascular repair, atherosclerosis, hypertension, CD34-positive cell, elderly men, Gerotarget

Received: May 24, 2016 Accepted: June 09, 2016 Published: June 22, 2016

Abstract

Platelets and circulating CD34-positive cells have been reported to contribute to vascular repair (endothelial repair and developing atherosclerosis). And because hypertension is known to be a strong vascular impairment factors, it should also influence the respective numbers of these factors. To clarify the clinical importance of platelets on vascular repair, we conducted a cross-sectional study of 567 Japanese men aged 60-69 who underwent an annual health check-up between 2013 and 2015. Multiple linear regression analysis of non-hypertensive subjects adjusting for classical cardiovascular risk factors showed that although platelet count did not significantly correlate with carotid intima media thickness (β = -0.05, p = 0.356), it did positively correlate significantly with the natural log of the number of circulating CD34-positive cells (β = 0.26, p < 0.001). In hypertensive subjects, a significant positive correlation was seen between platelets and intima media thickness (β = 0.19, p = 0.008), whereas no significant correlation was seen between platelet count and the natural log of the number of circulating CD34-positive cells (β = 0.11, p = 0.119). Our results indicate that platelet count is an indicator of vascular repair activity (endothelial repair and developing atherosclerosis). Additionally, hypertension might mask the beneficial effects of circulating CD34-positive cells.


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