Oncotarget

Clinical Research Papers:

Percutaneous intraductal radiofrequency ablation in the management of unresectable Bismuth types III and IV hilar cholangiocarcinoma

Yu Wang, Wei Cui, Wenzhe Fan, Yingqiang Zhang, Wang Yao, Kunbo Huang and Jiaping Li _

PDF  |  HTML  |  How to cite

Oncotarget. 2016; 7:53911-53920. https://doi.org/10.18632/oncotarget.10116

Metrics: PDF 2051 views  |   HTML 2351 views  |   ?  


Abstract

Yu Wang1,*, Wei Cui1,*, Wenzhe Fan1, Yingqiang Zhang1, Wang Yao1, Kunbo Huang1, Jiaping Li1

1Department of Interventional Oncology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China

*These authors contributed equally to this work

Correspondence to:

Jiaping Li, email: [email protected]

Keywords: radiofrequency ablation, percutaneous transhepatic cholangial drainage, metal stent, hilar cholangiocarcinoma

Received: March 13, 2016     Accepted: May 10, 2016     Published: June 17, 2016

ABSTRACT

Purpose: To assess the feasibility and safety of percutaneous intraductal radiofrequency ablation (RFA) for unresectable Bismuth types III and IV hilar cholangiocarcinoma.

Results: Percutaneous intraductal RFA combined with metal stent placement was successful in all patients without any technical problems; the technical success rate was 100%. Chemotherapy was administered to two patients. After treatment, serum direct bilirubin levels were notably decreased. Six patients died during the follow-up period. Median stent patency from the time of the first RFA and survival from the time of diagnosis were 100 days (95% confidence interval (CI), 85–115 days) and 5.3 months (95% CI, 2.5–8.1 months), respectively. No acute pancreatitis, bile duct bleeding and perforation, bile leakage, or other severe complications occurred. Four cases of procedure-related cholangitis, three cases of postoperative abdominal pain, and five cases of asymptomatic transient increase in serum amylase were observed. One patient who presented with stent blockage 252 days’ post-procedure underwent repeat ablation.

Materials and Methods: Between September 2013 and May 2015, nine patients with unresectable Bismuth types III and IV hilar cholangiocarcinoma who were treated with percutaneous intraductal RFA combined with metal stent placement after the percutaneous transhepatic cholangial drainage were included in the retrospective analysis. Procedure-related complications, stent patency, and survival after treatment were investigated.

Conclusion: Percutaneous intraductal RFA combined with metal stent placement is a technically safe and feasible therapeutic option for the palliative treatment of unresectable Bismuth types III and IV hilar cholangiocarcinoma. Its long-term efficacy and safety is promising, but needs further study via randomized and prospective trials that include a greater number of patients.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 10116