MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2

Xisheng Yang; Jianlin Wang; Shibin Qu; Hongtao Zhang; Bai Ruan; Yuan Gao; Ben Ma; Xing Wang; Nan Wu; Xiaolei Li; Kefeng Dou; Haimin Li

doi:10.18632/oncotarget.3486

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2

Xisheng Yang, Jianlin Wang, Shibin Qu, Hongtao Zhang, Bai Ruan, Yuan Gao, Ben Ma, Xing Wang, Nan Wu, Xiaolei Li, Kefeng Dou and Haimin Li _

PDF | HTML | How to cite

Oncotarget. 2015; 6:7918-7929. https://doi.org/10.18632/oncotarget.3486

Metrics: PDF 2452 views | HTML 2387 views | ?

Abstract

Xisheng Yang1,*, Jianlin Wang1,*, Shibin Qu1,*, Hongtao Zhang1, Bai Ruan1, Yuan Gao1, Ben Ma1, Xing Wang1, Nan Wu1, Xiaolei Li1, Kefeng Dou1 and Haimin Li1

1 Department of Hepatobiliary Surgery, The Xijing Hospital of The Fourth Military Medical Uiversity, Xi’an, China

* These authors contributed equally to this work

Correspondence to:

Haimin Li, email:

Keywords: MicroRNAs, Hepatocellular carcinoma, Side population, Metastasis

Received: November 22, 2014 Accepted: February 01, 2015 Published: March 08, 2015

Abstract

Although microRNA-200a (miR-200a) is frequently downregulated in cancer, its role in side population (SP) has not been investigated. In this study, 101 pairs of primary hepatocellular carcinoma (HCC) tissues and matched normal control tissues were analyzed for miR-200a expression and its clinicopathological value was determined. We found that miR-200a was downregulated in HCC/SP and this was associated metastasis. MiR-200a suppressed metastasis of SP cells. Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2. The associations between miR-200a, SP cells and ZEB2 were validated in HCC. These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 3486

Publication Alerts

Research Papers:

MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2

Abstract