Prognostic significance of the pretreatment prognostic nutritional index in patients with epithelial ovarian cancer

Naoko Komura; Seiji Mabuchi; Eriko Yokoi; Kotaro Shimura; Mahiru Kawano; Yuri Matsumoto; Tadashi Kimura

doi:10.18632/oncotarget.26914

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Research Papers:

Prognostic significance of the pretreatment prognostic nutritional index in patients with epithelial ovarian cancer

Naoko Komura, Seiji Mabuchi, Eriko Yokoi, Kotaro Shimura, Mahiru Kawano, Yuri Matsumoto and Tadashi Kimura

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Oncotarget. 2019; 10:3605-3613. https://doi.org/10.18632/oncotarget.26914

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Abstract

Naoko Komura1, Seiji Mabuchi1, Eriko Yokoi1, Kotaro Shimura1, Mahiru Kawano1, Yuri Matsumoto1 and Tadashi Kimura1

1 Departments of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan

Correspondence to:

Seiji Mabuchi,

email:

[email protected]

Keywords: ovarian cancer; prognostic nutritional index; clinical stage; survival; prognostic factor

Received: July 23, 2018 Accepted: April 14, 2019 Published: June 04, 2019

ABSTRACT

Objective

We retrospectively investigated the prognostic significance of the pretreatment prognostic nutritional index (PNI) in patients with epithelial ovarian cancer (EOC) according to the clinical stage.

Methods

The baseline characteristics and clinical outcomes of 308 EOC patients were collected and retrospectively reviewed. PNI was defined as 10 × serum albumin (g/L) + 0.005 × lymphocyte count (per mm³) in the peripheral blood. The cut-off value of PNI was defined by time-dependent receiver operating characteristics (ROC) analysis. Univariate or multivariate analysis was conducted to evaluate the association between pretreatment PNI, progression-free survival (PFS), and disease-specific survival (DSS) according to the clinical stage.

Results

The cut-off value of PNI was defined as 44.7 in early-stage patients and 42.9 in advanced-stage patient by ROC analysis, respectively. Although decreased PNI was not associated with short PFS or DSS in early-stage patients, it was significantly correlated with short PFS (p<0.0001) and DSS (p<0.0001) in advanced-stage patients. In multivariate analysis, decreased PNI was an independent prognostic predictor of recurrence and short survival in advanced-stage patients.

Conclusion

A decreased pretreatment PNI was an independent poor prognostic factor in patients with advanced EOC.

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Research Papers:

Prognostic significance of the pretreatment prognostic nutritional index in patients with epithelial ovarian cancer

Abstract