Identification of a three miRNA signature as a novel potential prognostic biomarker in patients with bladder cancer

Fei Peng; Hui Li; Hailang Xiao; Ling Li; Yan Li; Yi Wu

doi:10.18632/oncotarget.22318

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Research Papers:

Identification of a three miRNA signature as a novel potential prognostic biomarker in patients with bladder cancer

Fei Peng, Hui Li, Hailang Xiao, Ling Li, Yan Li and Yi Wu _

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Oncotarget. 2017; 8:105553-105560. https://doi.org/10.18632/oncotarget.22318

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Abstract

Fei Peng1,*, Hui Li2,*, Hailang Xiao3, Ling Li3, Yan Li4 and Yi Wu1

1Department of Laboratory, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People’s Hospital, Changsha, China

2Reproductive Department, Xiangya Hospital, Central South University, Changsha, China

3Nephrology Department, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People’s Hospital, Changsha, China

4Department of Paediatrics, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People’s Hospital, Changsha, China

*These authors have contributed equally to this work

Correspondence to:

Yi Wu, email: [email protected]

Keywords: BLCA; miRNA; prognosis; biomarker; TCGA

Received: November 23, 2016 Accepted: June 20, 2017 Published: November 06, 2017

ABSTRACT

There is not a good biomaker that is closely related to survival time for bladder cancer(BLCA), The aim of the study is to identify a miRNA signature that could predict prognosis in BLCA patients according to the data from The Cancer Genome Atlas (TCGA). a total of 377 BLCA patients were finally enrolled in the study. The three miRNA signature was identified by Multivariate Cox proportional hazards analyses that common clinical variables were controled. The three microRNA signature showed greater predicting prognosis capacity for predicting 5-year survival in BLCA with an AUC of 0.664, 0.681 and 0.668 in Train set, Test set and Total set respectively. Furthermore, there was a significant difference between high score and low score in Total set(P=3e-05), Test set(P=0.00435) and Train set(P=0.00143), respectively. Therefore, these results provided a new prospect for prognostic biomarker of BLCA.

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Research Papers:

Identification of a three miRNA signature as a novel potential prognostic biomarker in patients with bladder cancer

Abstract