Elevated CD147 expression is associated with shorter overall survival in non-small cell lung cancer

Xiaojun Zhang; Tian Tian; Xiaofeng Zhang; Changting Liu; Xiangqun Fang

doi:10.18632/oncotarget.16948

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Elevated CD147 expression is associated with shorter overall survival in non-small cell lung cancer

Xiaojun Zhang, Tian Tian, Xiaofeng Zhang, Changting Liu _ and Xiangqun Fang

PDF | HTML | How to cite

Oncotarget. 2017; 8:37673-37680. https://doi.org/10.18632/oncotarget.16948

Metrics: PDF 1939 views | HTML 2141 views | ?

Abstract

Xiaojun Zhang1, Tian Tian1, Xiaofeng Zhang1, Changting Liu1 and Xiangqun Fang1

1Nanlou Respiratory Diseases Department, Chinese PLA General Hospital, Beijing 100853, P. R. China

Correspondence to:

Changting Liu, email: [email protected]

Xiangqun Fang, email: [email protected]

Keywords: CD147, lung cancer, meta-analysis, prognosis, survival

Received: December 28, 2016 Accepted: March 13, 2017 Published: April 07, 2017

ABSTRACT

A number of studies have reported on the prognostic role of CD147 expression in non-small cell lung cancer (NSCLC); however, the results remain controversial. This study aims to investigate the impact of CD147 on the prognosis of NSCLC by means of a meta-analysis. A literature search was performed for relevant studies published before October 29, 2016. The hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated as effective measures. Sensitivity analysis and publication bias examination were also conducted. Ten eligible studies with a total of 1605 patients were included in this meta-analysis. CD147 overexpression was correlated with poor overall survival (OS) (HR=1.59, 95% CI=1.32–1.91, p<0.001). Elevated CD147 expression was associated with the presence of lymph node metastasis (OR=2.31, 95% CI=1.74–3.07, p<0.001) and advanced TNM stage (OR=3.03, 95% CI=1.24–7.39, p=0.015). However, no significant association between CD147 and sex, age, differentiation, or histology was found. No evidence of significant publication bias was identified. This meta-analysis revealed that overexpression of CD147 was associated with shorter OS, the presence of lymph node metastasis and advanced TNM stage in NSCLC. Therefore, CD147 could serve as a potential prognostic marker for NSCLC.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 16948

Publication Alerts

Research Papers:

Elevated CD147 expression is associated with shorter overall survival in non-small cell lung cancer

Abstract