AID-induced remodeling of immunoglobulin genes and B cell fate

Brice Laffleur; Nicolas Denis-Lagache; Sophie Péron; Christophe Sirac; Jeanne Moreau; Michel Cogné

doi:10.18632/oncotarget.1546

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

AID-induced remodeling of immunoglobulin genes and B cell fate

Brice Laffleur, Nicolas Denis-Lagache, Sophie Péron, Christophe Sirac, Jeanne Moreau and Michel Cogné _

PDF | HTML | How to cite

Oncotarget. 2014; 5:1118-1131. https://doi.org/10.18632/oncotarget.1546

Metrics: PDF 3027 views | HTML 3226 views | ?

Abstract

Brice Laffleur1,2, Nicolas Denis-Lagache1,2, Sophie Péron1,2, Christophe Sirac1,2, Jeanne Moreau1,2 and Michel Cogné1,2,3

1 Limoges University, Limoges France ;

2 Centre National de la Recherche Scientifique,

3 Institut Universitaire de France, Limoges, France

Correspondence:

Michel Cogné, email:

Keywords: AID; B cell fate; BCR, immunoglobulin genes

Received: October 28, 2013 Accepted: December 12, 2013 Published: December 14, 2013

Abstract

Survival and phenotype of normal and malignant B lymphocytes are critically dependent on constitutive signals by the B cell receptor (BCR) for antigen. In addition, either antigen ligation of the BCR or various mitogenic stimuli result in B cell activation and induction of activation-induced deaminase (AID). AID activity can in turn mediate somatic hypermutation (SHM) of immunoglobulin (Ig) V regions and also deeply remodel the Ig heavy chain locus through class switch recombination (CSR) or locus suicide recombination (LSR). In addition to changes linked to affinity for antigen, modifying the class/isotype (i.e. the structure and function) of the BCR or suddenly deleting BCR expression also modulates the fate of antigen-experienced B cells.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 1546

Publication Alerts

Reviews:

AID-induced remodeling of immunoglobulin genes and B cell fate

Abstract